abstract：:The incidence of stress-induced psychological and somatic diseases has been increasing rapidly, and it is important to clarify the neurophysiological mechanisms of stress response in order to establish effective stress management methods. We previously reported that the prefrontal cortex (PFC) plays an important role ...

journal_title：Advances in experimental medicine and biology

authors： Nagasawa Y,Ishida M,Komuro Y,Ushioda S,Hu L,Sakatani K

更新日期：2020-01-01 00:00:00

abstract：:Hypoxic ischemic encephalopathy (HIE) leads to significant mortality and morbidity, and therapeutic hypothermia (TH) has become a standard of care following HIE. After TH, the body temperature is brought back to 37 °C. Early electroencephalography (EEG) is a reliable outcome biomarker following HIE. We hypothesized th...

journal_title：Advances in experimental medicine and biology

authors： Mitra S,Bale G,de Roever I,Meek J,Robertson NJ,Tachtsidis I

更新日期：2020-01-01 00:00:00

abstract：:Inhalation of high concentrations of zinc oxide (ZnO) particles may cause metal fume fever. A useful tool to characterize the reactivity of innate immune cells of an individual, e.g., after in vivo exposure, is the whole blood assay (WBA). The measurable outcome of WBA is the release of cytokines, especially pro-infla...

journal_title：Advances in experimental medicine and biology

authors： Liebers V,Kendzia B,Monsé C,Jettkant B,Stubel H,Borowitzki G,Hagemeyer O,Brüning T,Merget R,Raulf M

更新日期：2020-01-01 00:00:00

abstract：:Suppression of tumorigenicity 2 (ST2), also known as interleukin-1 receptor-like 1 (IL1RL1), is one of the natural receptors of IL-33. Three major isoforms, ST2L (transmembrane form), sST2 (soluble form), and ST2V, are generated by alternative splicing. Damage to stromal cells induces necrosis and release of IL-33, wh...

journal_title：Advances in experimental medicine and biology

authors： Chang CP,Hu MH,Hsiao YP,Wang YC

更新日期：2020-01-01 00:00:00

abstract：:Environmental and iatrogenic exposures contribute significantly to human diseases, including cancer. The list of known human carcinogens has recently been extended by the addition of aristolochic acids (AAs). AAs occur primarily in Aristolochia herbs, which are used extensively in folk medicines, including Traditional...

journal_title：Advances in experimental medicine and biology

authors： Sidorenko VS

更新日期：2020-01-01 00:00:00

abstract：:During central nervous system (CNS) development, a complex series of events play out, starting with the establishment of neural progenitor cells, followed by their asymmetric division and formation of lineages and the differentiation of neurons and glia. Studies in the Drosophila melanogaster embryonic CNS have reveal...

journal_title：Advances in experimental medicine and biology

authors： Bahrampour S,Thor S

更新日期：2020-01-01 00:00:00

abstract：:Lung diseases affect millions of individuals all over the world. Various environmental factors, such as toxins, chemical pollutants, detergents, viruses, bacteria, microbial dysbiosis, and allergens, contribute to the development of respiratory disorders. Exposure to these factors activates stress responses in host ce...

journal_title：Advances in experimental medicine and biology

authors： Chen J,Jin Y,Yang Y,Wu Z,Wu G

更新日期：2020-01-01 00:00:00

abstract：:Tumor-associated neutrophils (TANs) play a major role during cancer development and progression in the tumor microenvironment. Neutrophil elastase (NE) is a serine protease normally expressed in neutrophil primary granules. Formation of neutrophil extracellular traps (NETs), a mechanism used by neutrophils, has been t...

journal_title：Advances in experimental medicine and biology

authors： Huang H,Zhang H,Onuma AE,Tsung A

更新日期：2020-01-01 00:00:00

abstract：:The key purpose of phagocytosis is the destruction of pathogenic microorganisms. The phagocytes exert a wide array of killing mechanisms that allow mastering the vast majority of pathogens. One of these mechanisms consists in the production of reactive oxygen species inside the phagosome by a specific enzyme, the phag...

journal_title：Advances in experimental medicine and biology

authors： Valenta H,Erard M,Dupré-Crochet S,Nüβe O

更新日期：2020-01-01 00:00:00

abstract：:Complementary and alternative medicine (CAM) encompasses a wide range of different nonmainstream therapies that have been increasingly used for treatment or adjunctive treatment of various ailments with anxiety/anxiety disorders being one of the commonly CAM (self)-medicated conditions. Thousands of published papers r...

journal_title：Advances in experimental medicine and biology

authors： Trkulja V,Barić H

更新日期：2020-01-01 00:00:00

abstract：:Insulin secretion in humans is usually induced by mixed meals, which upon ingestion, increase the plasma concentration of glucose, fatty acids, amino acids, and incretins like glucagon-like peptide 1. Beta-cells can stay in the off-mode, ready-mode or on-mode; the mode-switching being determined by the open state prob...

journal_title：Advances in experimental medicine and biology

authors： Islam MS

更新日期：2020-01-01 00:00:00

abstract：:Under the partial influences of paradigm shift form category to dimension, the Diagnostic and Statistical Manual of Mental Disorder (DSM) was revised to the fifth edition (DSM-5); however, due to the lack of consistent biological makers and processes and the restricted availability of dimensional meta-structure, the r...

journal_title：Advances in experimental medicine and biology

authors： Park SC,Kim YK

更新日期：2020-01-01 00:00:00

abstract：:Neurons are long-lived post-mitotic cells that possess an elaborate system of endosomes and lysosomes (endolysosomes) for protein quality control. Relatively recently, endolysosomes were recognized to contain high concentrations (400-600 μM) of readily releasable calcium. The release of calcium from this acidic organe...

journal_title：Advances in experimental medicine and biology

authors： Lakpa KL,Halcrow PW,Chen X,Geiger JD

更新日期：2020-01-01 00:00:00

abstract：:Network-based approach for psychological phenotypes assumes the dynamical interactions among the psychiatric symptoms, psychological characteristics, and neurocognitive performances arise, as they coexist, propagate, and inhibit other components within the network of mental phenomena. For differential types of dataset...

journal_title：Advances in experimental medicine and biology

authors： Yun JY,Kim YK

更新日期：2020-01-01 00:00:00

abstract：:Store-operated Ca2+ entry (SOCE) is a ubiquitous mechanism for Ca2+ influx in mammalian cells with important physiological implications. Since the discovery of SOCE more than three decades ago, the mechanism that communicates the information about the amount of Ca2+ accumulated in the intracellular Ca2+ stores to the ...

journal_title：Advances in experimental medicine and biology

authors： Lopez JJ,Jardin I,Albarrán L,Sanchez-Collado J,Cantonero C,Salido GM,Smani T,Rosado JA

更新日期：2020-01-01 00:00:00

abstract：:Cardiac arrhythmias are common diseases affecting millions of people worldwide. A broad and diverse array of arrhythmias exists, ranging from harmless ones such as sinus arrhythmia to fatal disorders such as ventricular fibrillation. The underlying pathophysiology of arrhythmogenesis is complex and still not fully und...

journal_title：Advances in experimental medicine and biology

authors： Kleeberger JA,Tomsits PJ,Kääb S,Clauss S

更新日期：2020-01-01 00:00:00

abstract：:Calcium (Ca2+) buffering is part of an integrative crosstalk between different mechanisms and elements involved in the control of free Ca2+ ions persistence in the cytoplasm and hence, in the Ca2+-dependence of many intracellular processes. Alterations of Ca2+ homeostasis and signaling from systemic to subcellular lev...

journal_title：Advances in experimental medicine and biology

authors： Gilabert JA

更新日期：2020-01-01 00:00:00

abstract：:Non-coding RNA (ncRNA) is a class of RNAs that are not act as translational protein templates. They are involved in the regulation of gene transcription, RNA maturation and protein translation, participating in a variety of physiological and physiological processes. NcRNAs have important functions, and are recently on...

journal_title：Advances in experimental medicine and biology

authors： Wang L,Wang J,Li G,Xiao J

更新日期：2020-01-01 00:00:00

abstract：:Stem cells having the capability to differentiate into other type of cells and renewing themselves, gained so much importance in recent years. Investigations in stem cells revealed that mesenchymal stem cells can successfully differentiate into other type of cells like adipocytes, hepatocytes, osteocytes, neurocytes a...

journal_title：Advances in experimental medicine and biology

authors： Aydin S,Sağraç D,Şahin F

更新日期：2020-01-01 00:00:00

abstract：:Cancer is considered the disease of the century, which can be easily understood considering its increasing incidence worldwide. Over the last years, nanotechnology has been presenting promising theranostic approaches to tackle cancer, as the development of nanoparticle-based therapies. But, regardless of the promising...

journal_title：Advances in experimental medicine and biology

authors： Maia FR,Reis RL,Oliveira JM

更新日期：2020-01-01 00:00:00

abstract：:Cell proliferation, apoptosis and differentiation are essential processes from the early phases of embryogenesis to adult tissue formation and maintenance. These mechanisms also play a key role in embryonic stem cells (ESCs) that are able to proliferate maintaining pluripotency and, at the same time, to give rise to a...

journal_title：Advances in experimental medicine and biology

authors： Pennarossa G,Paffoni A,Ragni G,Gandolfi F,Brevini TAL

更新日期：2020-01-01 00:00:00

abstract：:Several major cardiovascular diseases, such as heart failure (HF) and atherosclerosis (AS), have been linked to autophagy dysfunction. The influence of autophagy on the occurrence and development of cardiovascular diseases has two sides. Generally, the induction of autophagy at a low level can provide energy and nutri...

journal_title：Advances in experimental medicine and biology

authors： Gu S,Li X

更新日期：2020-01-01 00:00:00

abstract：:Multiple myeloma is a hematological malignancy. It is characterized by the abnormal clonal proliferation of malignant plasma cells in the bone marrow and the secretion of a large number of monoclonal immunoglobulins or light chains, causing bone destruction, elevated blood calcium levels, anemia, and renal dysfunction...

journal_title：Advances in experimental medicine and biology

authors： Zheng Z,Wang L,Cheng S,Wang Y,Zhao W

更新日期：2020-01-01 00:00:00

abstract：:Autophagy is an endogenous and essential process which maintains cellular homeostasis and directs cell fate. The glomerular diseases are one main part of the kidney diseases, often associated with poor clinical outcomes. The regulation of autophagy contributes to the progression of various glomerular diseases, includi...

journal_title：Advances in experimental medicine and biology

authors： Cui J,Bai X,Chen X

更新日期：2020-01-01 00:00:00

abstract：:Radiotherapy is an important component of cancer treatment modalities. With the rapid development of three-dimensional conformal, intensity-modulated, image-guided radiotherapy and the efficacy of radiotherapy continues to improve. Autophagy, as a catabolic process, is characterized by the formation of a double-membra...

journal_title：Advances in experimental medicine and biology

authors： Gao L,Zheng H,Cai Q,Wei L

更新日期：2020-01-01 00:00:00

abstract：:Myocardial ischemia and reperfusion cause injury to the heart in myocardial ischemic disease. Both processes increase autophagy. In this chapter, we will provide an overview of the autophagic mechanism caused by myocardial ischemia/reperfusion injury and the role of autophagy in myocardial ischemia/reperfusion injury....

journal_title：Advances in experimental medicine and biology

authors： Du J,Li Y,Zhao W

更新日期：2020-01-01 00:00:00

abstract：:Metastasis is the major cause of breast cancer death worldwide. In metastatic breast cancer, circulating tumor cells (CTCs) can be captured from patient blood samples sequentially over time and thereby serve as surrogates to assess the biology of surviving cancer cells that may still persist in solitary or multiple me...

journal_title：Advances in experimental medicine and biology

authors： Kujur PK,Flores BCT,Ramalingam N,Chinen LTD,Jeffrey SS

更新日期：2020-01-01 00:00:00

abstract：:Lysosomal storage disorders (LSDs) are one of the most common human genetic metabolic diseases caused by gene mutations. Up to now, more than 70 LSDs have been identified and mainly divided into five categories. LSDs are mainly caused by defects in the function of enzymes or lysosomal-related proteins in lysosomes, wh...

journal_title：Advances in experimental medicine and biology

authors： Ren H,Wang G

更新日期：2020-01-01 00:00:00

abstract：:The gastrointestinal (GI) tract consists of a remarkable series of organs that spatially and temporally coordinate the vital process of digestion to extract key nutrients required to sustain our day-to-day functions. During development, it undergoes complex and highly specialized morphogenetic events to form functiona...

journal_title：Advances in experimental medicine and biology

authors： Smith RJ,Francis R,Kim JE,Kim TH

更新日期：2020-01-01 00:00:00

abstract：:Metformin is a safe, effective and useful drug for glucose management in patients with diabetes. However in recent years, more attention has been paid to the possibility of using metformin as an anti-aging drug. It was shown to significantly increase the lifespan in some model organisms and delay the onset of age-asso...

journal_title：Advances in experimental medicine and biology

authors： Piskovatska V,Storey KB,Vaiserman AM,Lushchak O

更新日期：2020-01-01 00:00:00

abstract：:Transamniotic stem cell therapy (TRASCET) is a novel prenatal therapeutic alternative for the treatment of congenital anomalies. It is based upon the principle of augmenting the pre-existing biological role of select populations of fetal stem cells for targeted therapeutic benefit. For example, amniotic fluid-derived ...

journal_title：Advances in experimental medicine and biology

authors： Lazow SP,Fauza DO

更新日期：2020-01-01 00:00:00

abstract：:Our own studies and those of others have shown that defects in essential fatty acid (EFA) metabolism occurs in age-related disorders such as obesity, type 2 diabetes mellitus, hypertension, atherosclerosis, coronary heart disease, immune dysfunction and cancer. It has been noted that in all these disorders there could...

journal_title：Advances in experimental medicine and biology

authors： Das UN

更新日期：2020-01-01 00:00:00

abstract：:Systemic effects of COPD lead to cardiovascular co-morbidities, muscle wasting and osteoporosis that, in turn, lead to inactivity and physical deconditioning. This evolution has a direct influence on the health-related quality of life (HRQoL) of patients suffering from this respiratory disease. Pharmacological therapy...

journal_title：Advances in experimental medicine and biology

authors： Fiorentino G,Esquinas AM,Annunziata A

更新日期：2020-01-01 00:00:00

abstract：:Accumulating evidence has demonstrated that exercise training not only reduces cardiovascular disease risk but also provides direct endogenous cardiovascular protection. The mechanisms that have been proposed to be responsible for exercise-induced cardioprotection include intrinsic myocardial changes such as increased...

journal_title：Advances in experimental medicine and biology

authors： Li G,Li J,Gao F

更新日期：2020-01-01 00:00:00

abstract：:Class XVIII myosins represent a branch of the myosin family tree characterized by the presence of large N- and C-terminal extensions flanking a generic myosin core. These myosins display the highest sequence similarity to conventional class II muscle myosins and are compatible with but not restricted to myosin-2 contr...

journal_title：Advances in experimental medicine and biology

authors： Taft MH,Latham SL

更新日期：2020-01-01 00:00:00

abstract：:Cellular organization through cytoskeletal trafficking is a process of fundamental importance. Highly specialized systems evolved that enable motors to identify and select the optimal tracks for motility. In this chapter, we examine the profound effect of actin filament networks on myosin motility patterns. We argue t...

journal_title：Advances in experimental medicine and biology

authors： Santos A,Shauchuk Y,Cichoń U,Vavra KC,Rock RS

更新日期：2020-01-01 00:00:00

abstract：:Chronic heart failure, diabetes, depression, and other chronic diseases are associated with high mortality rate and low cure rate. Exercise induces muscle contraction and secretes multiple myokines, which affects the signaling pathways in skeletal muscle tissues and regulate remote organ functions. Exercise is known t...

journal_title：Advances in experimental medicine and biology

authors： Fan Z,Xu M

更新日期：2020-01-01 00:00:00

abstract：:Cancers are complex tissues composed by genetically altered cancer cells and stromal elements such as inflammatory/immune cells, fibroblasts, endothelial cells and pericytes, neuronal cells, and a non-cellular component, the extracellular matrix. The complex network of interactions and crosstalk established between ca...

journal_title：Advances in experimental medicine and biology

authors： Mendes N,Dias Carvalho P,Martins F,Mendonça S,Malheiro AR,Ribeiro A,Carvalho J,Velho S

更新日期：2020-01-01 00:00:00

abstract：:The Wnt signaling pathways are well known for having several pivotal roles during embryonic development. However, the same developmental signaling pathways also present key roles in cancer initiation and progression. In this chapter, several issues regarding the roles of both canonical and non-canonical Wnt signaling ...

journal_title：Advances in experimental medicine and biology

authors： Carreira-Barbosa F,Nunes SC

更新日期：2020-01-01 00:00:00

abstract：:The clinical challenge on surface engineering of medical devices to prevent microorganisms adhesion and biofilm formation, has become an essential aspect for medical implants. Antibacterial properties of Graphene Oxide (GO) have been demonstrated across a broad spectrum of bacteria, and the different mechanisms of act...

journal_title：Advances in experimental medicine and biology

authors： Cacaci M,Martini C,Guarino C,Torelli R,Bugli F,Sanguinetti M

更新日期：2020-01-01 00:00:00